منابع مشابه
Structure Based Antibody-Like Peptidomimetics
Biologics such as monoclonal antibodies (mAb) and soluble receptors represent new classes of therapeutic agents for treatment of several diseases. High affinity and high specificity biologics can be utilized for variety of clinical purposes. Monoclonal antibodies have been used as diagnostic agents when coupled with radionuclide, immune modulatory agents or in the treatment of cancers. Among ot...
متن کاملPeptides and peptidomimetics as prototypes.
Helma Wennemers HW received her master (Diploma) degree in chemistry from the University of Frankfurt in 1993 and her PhD degree from Columbia University New York in 1996. After two years as a postdoctoral researcher at Nagoya University, she joined the faculty at the University of Basel where she is now associate professor of chemistry. Her research focuses on the use of peptides in supramolec...
متن کاملThe Potential Therapeutic Application of Peptides and Peptidomimetics in Cardiovascular Disease
Cardiovascular disease (CVD) remains a leading cause of mortality and morbidity worldwide. Numerous therapies are currently under investigation to improve pathological cardiovascular complications, but yet, there have been very few new medications approved for intervention/treatment. Therefore, new approaches to treat CVD are urgently required. Attempts to prevent vascular complications usually...
متن کاملDiversity-oriented synthesis of macrocyclic peptidomimetics.
Structurally diverse libraries of novel small molecules represent important sources of biologically active agents. In this paper we report the development of a diversity-oriented synthesis strategy for the generation of diverse small molecules based around a common macrocyclic peptidomimetic framework, containing structural motifs present in many naturally occurring bioactive compounds. Macrocy...
متن کاملHigh throughput synthesis of peptides and peptidomimetics.
Peptide synthesis has been developed into one of the most efficient synthetic procedures in organic chemistry. The problems of orthogonal functional group protection and amide bond formation without racemization have been developed in a number of ingenious strategies. Optimization, in particular, has been achieved in stepwise solid phase synthesis. This in turn made possible the development of ...
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ژورنال
عنوان ژورنال: Nature Reviews Urology
سال: 2017
ISSN: 1759-4812,1759-4820
DOI: 10.1038/nrurol.2017.59